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Introduction Several types of cancers including
2019-04-28
Introduction Several types of cancers, including those originating in the breast, prostate, and lung, have a propensity to metastasize to the bones [1,2]. Bone metastases severely impair skeletal metabolism, and result in important clinical sequelae, such as excruciating chronic bone pain and the s
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br Materials and methods br Results
2019-04-28
Materials and methods Results Discussion To our best knowledge, a multi-modality approach to systematically characterize an OS in vivo orthotopic model, using an aggressive OS cell line has not been previously reported. The advantage of using multi-modality approach i.e. BLI, histopathology
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The majority of breast malignancies are
2019-04-28
The majority of breast malignancies are hormone responsive, and adjuvant endocrine therapy is used routinely to prevent breast cancer recurrence and death [6,7]. Tamoxifen was the past treatment of choice for endocrine-responsive postmenopausal breast cancer and was found to preserve BMD in postmeno
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After overdrive pacing excitation that is one
2019-04-28
After overdrive pacing, excitation that is one lap behind (the second beat after the stimulus) is caused by several mechanisms. One is the prolonged conduction time that is longer than the TCL due to a long conduction pathway and/or slow conduction. The other is the dual-loop reentry [12]. The excit
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Vaccinated individuals might represent a safer
2019-04-28
Vaccinated individuals might represent a safer source of hyperimmune serum. Two vaccine candidates will be tested soon in west Africa. If serum from vaccinated individuals has neutralising activity against the virus in cell models, this serum could be used as adjuvant therapy for EVD. In parallel, a
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In vitro test for EEC JAK
2019-04-28
In vitro test for EEC, JAK2 mutations and paraclinical parameters were performed by routine analysis. Discussion It is always important to make the correct diagnosis – in particular when molecular biological analyses are available. The pursuit of the correct diagnosis was intensified in these P
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Roughly years have gone by since the identification
2019-04-26
Roughly 15 years have gone by since the identification of the main characters involved in the interplay of the RANK–RANKL system. This gave rise to the race for elucidating their biological role . In those years, in vivo silencing experiments for both Receptor Activator of Nuclear Factor κ B (RANK)
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It is noteworthy that in a recent study Le
2019-04-26
It is noteworthy that in a recent study, Le Scouarnec et al. [199]. estimated the burden of rare coding variation in arrhythmia susceptibility genes among 167 BrS index patients and compared that with 167 individuals ≥65 years old with no history of cardiac arrhythmia. The authors concluded that, ex
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The congruence between BrS and ERS with
2019-04-26
The congruence between BrS and ERS with respect to clinical manifestations and response to therapy lends further support to the repolarization hypothesis. Using an experimental model of ERS, Koncz et al. [30]. recently provided evidence in support of the hypothesis that, similar to the mechanism ope
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A year old female patient
2019-04-26
A 55-year-old female patient was referred to us for BMS 777607 of an implantable cardioverter-defibrillator (ICD) after cardiac arrest due to idiopathic ventricular fibrillation. As she was young and had no indications for cardiac resynchronization therapy or bradycardia support, she was screened f
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El eje dram tico de En la prisi
2019-04-26
El eje dramático de En la prisión… se va desarrollando Merimepodib través de los relatos que el Profesor, un militante de la vanguardia política revolucionaria cubana, sueña que, a su vez sueña, que narra a un grupo de “negros” durante un agobiante verano habanero de los años noventa. Todo sucede de
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In subgroup analysis of the types of
2019-04-26
In subgroup analysis of the types of hospice as classified by the administrative authorities (Table 3), there was a trend that the patients admitted to a public hospital had a higher rate of dying in a hospice than those admitted to a private hospital, especially in the military and veterans\' hospi
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In DC from A group only
2019-04-26
In DC from A group only few genes appeared to be significantly and highly modulated (10 out of 84). The HIV natural ligands CCL4 and CD4, the HIV induced transcription factor IRF1 as well as the apoptotic genes BAD and CASP8 resulted down-regulated compared to monocytes at all the considered time po
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daunorubicin br The indications for ICD
2019-04-26
The indications for ICD placement for the secondary prevention of sudden cardiac death Some patients with underlying daunorubicin disease and/or LV dysfunction die from tachyarrhythmias even after ICD placement [18]. However, no arrhythmic deaths occurred during the implantation or during the fol
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Cisplatin based chemotherapy is commonly used in
2019-04-26
Cisplatin-based chemotherapy is commonly used in adjuvant CCRT, but data on carboplatin-based chemotherapy with radiotherapy is lacking. Khoury et al reported that patients treated with carboplatin-based chemoradiotherapy show worse outcomes. However, the impact on patient comorbidities was not repo
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