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Progress toward the treatment of three major
2018-11-05
Progress toward the treatment of three major parasitic diseases (sleeping sickness, Chagas disease, and leishmaniasis) was recently demonstrated in an article published online last month in the journal (August 8, 2016). Collectively, these three diseases affect 20 million people per year, resulting
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br Outstanding Questions The therapeutics
2018-11-05
Outstanding Questions The therapeutics mentioned in this review are a small sample of some of the most promising clinical pharmacological approaches to tackling age-related diseases. Assessing the potential systemic anti-ageing effects of therapeutics currently used to treat specific age-related
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br Case report A year old boy
2018-11-05
Case report A 15-year-old boy complaining of unexplained fatigue was first attended by the pediatrics office on November 2010. Such discomfort started in June, two months after being vaccinated against the 2009 pandemic influenza A/H1N1 virus with Pandemrix™. Physical and neurological examination
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br Summary br Introduction br Respiratory rehabilitation pro
2018-11-05
Summary Introduction Respiratory rehabilitation program Muscular training is the key factor of the respiratory rehabilitation program described in this paper. The exercises are grouped according to the body area of interest into local exercises (involving nose, lips, antigravity muscles of
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glucose transporter Electrochemical experiments cyclic volta
2018-11-05
Electrochemical experiments (cyclic voltammetry (CV)) were performed using Autolab Potentiostat/Galvanostat (Eco Chemie, Netherlands) with three-electrode cell where L/IL/ITO (laponite/Ionic Liquid/ITO) was used as working electrode, platinum (Pt) wire as the auxiliary electrode and Ag/AgCl as refer
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ccr5 inhibitor M hominis is not stainable by Gram stain and
2018-11-03
M. hominis is not stainable by Gram stain and recognition of its pinpoint-sized colonies requires experienced laboratory personnel. BacT/ALERT and BACTEC media (used for blood cultures) contain sodium polyanethol sulfonate, which may inhibit Mycoplasma growth (Waites and Canupp, 2001), and growth ma
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Although the role of CP against pneumococcal
2018-11-03
Although the role of CP against pneumococcal infection has been investigated, the two studies provided opposing findings with varying mechanisms for CP to either inhibit or facilitate pneumococcal virulence. One study reported that CP is an anti-pneumococcal host factor that inhibits bacterial growt
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br Conflict of Interest Statement br
2018-11-03
Conflict of Interest Statement Author Contributions N.M., K.N., M.G., R.J.O., and M.K. performed in vitro and in vivo experiments; N.M., H.D., and M.K., performed protein purification, crystallization, data collection, structure determination, and structural analyses; P.C., and J.D.H. carried
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br Value of the data
2018-11-03
Value of the data Data This dataset collates the comprehensive proteomic data generated through a SILAC-based quantitative MS approach upon silencing the 65 tyrosine kinases expressed in MCF7 breast cancer AVE 0991 [1]. In addition to the raw data files deposited in the Pride database [2,3],
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br Methods br Results br Discussion br
2018-11-03
Methods Results Discussion Introduction The use of institutional care for abandoned or orphaned infants and children has remained a common practice throughout the world (Browne et al., 2006; UNICEF, 2015); however, institutional environments are harmful for healthy physical and psycholog
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br A potential adaptive role of dopaminergic reactivity in
2018-11-03
A potential adaptive role of dopaminergic reactivity in adolescence The view that peaks in DA activity during adolescence underlie increases in risk taking and adolescent psychopathology suggests that adolescents are predisposed toward mental health problems due to hard-wired developmental const
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One explanation for the range of findings observed in the
2018-11-03
One explanation for the range of findings observed in the current study is that there may be a developmental delay in the formation of the cortical–cortical and corticospinal motor networks in TS. As noted above, motor threshold is thought to depend upon the recruitment of a coherent population of c
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Yet in spite of the increasing number of
2018-11-03
Yet, in spite of the increasing number of publications on adults, the neurocognitive mechanisms underlying TO in children are less clear. In a recent study, Johnson and collaborators (Johnson et al., 2015) employed a combined spatio-temporal cueing paradigm and found behavioural evidence that 6–16-y
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In surveying the literature support for attention biases tow
2018-11-03
In surveying the literature, support for attention biases towards appetitive cues appears in the substance abuse and obesity literatures. For example, attention bias towards drug-related cues has been found among alcohol (Field et al., 2004), tobacco (Bradley et al., 2003; Mogg et al., 2005), caffei
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Taken together studies of both neuroanatomy
2018-11-03
Taken together, studies of both neuroanatomy and neural functional activation yield SES-related differences in sglt regions that support language; these findings, however, have not reliably been linked to differences in language functioning. Importantly, a recent study has shown no measurable diffe
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