• Here we show that cholesterol metabolites play an important

  2018-10-20

  

  Here, we show that cholesterol metabolites play an important role in cardiac differentiation in mouse embryonic stem cells (mESC). Gcrt receptor expression in the early mouse embryo and its exclusive localization to cell nuclei within the visceral endoderm then prompted us to further investigate a p

• We have recently developed a new cell delivery system that

  2018-10-20

  

  We have recently developed a new cell delivery system that enabled the transplantation of hBM-MSCs as a thin layer across the extravascular spaces of the choroid in RCS rats. The graft covered most of the area of the back of the eye via a single injection with no retinal detachment or choroidal hemo

• br Material and methods br Results

  2018-10-20

  

  Material and methods Results Discussion Aging-associated phenotype change in hBMSCs is one of the most important considerations in furthering the advancement of cell-based therapy and is a subject of numerous studies and reviews (Baker et al., 2015; Bara et al., 2014). In regard to the in v

• In addition to supplying a source of growth factors

  2018-10-20

  

  In addition to supplying a source of growth factors and signaling molecules, blood vessels also provide a physical framework that can support the migration of neural progenitors during development and in the adult XL184 (Whitman et al., 2009). In the embryonic and adult rodent SVZ, newly born proge

• br Conclusion Cellular reprogramming is an inefficient proce

  2018-10-20

  

  Conclusion Cellular reprogramming is an inefficient process and obtaining the rare reprogramming intermediates is a major hurdle in understanding this important event at the molecular level. The application of certain techniques that require higher cell numbers such as transcription factor UNC202

• br Materials and methods br Results br

  2018-10-20

  

  Materials and methods Results Discussion We have identified and begun to characterize a novel miRNA, miR-410, which on inhibition of BMP signaling by Noggin, is down-regulated in the adult SVZ. Over-expression of miR-410 in SVZ neurospheres inhibited neuronal differentiation and increased t

• CSCs are identified either by surface

  2018-10-20

  

  CSCs are identified either by surface markers and up-regulation of transcription factors/other genes involved in stem cell pathways or by functional assays to characterize stem like properties like drug efflux, quiescence and self-renewal (Moserle et al., 2010). Studies have reported enrichment of C

• In this regard murine ESC derivatives bearing

  2018-10-20

  

  In this regard, murine ESC derivatives bearing EGFP transcriptionally controlled via the promoter of the HCN4 gene were reported to coexpress EGFP, HCN4, and other cardiac markers in spontaneously beating foci (Morikawa et al., 2010). Yet, after the EGFP-positive fraction was subjected to cell sorti

• There are three possible explanations for our findings First

  2018-10-20

  

  There are three possible explanations for our findings. First, it is possible that the reprogramming process resulted in iPSCs that were solely derived from methylated FM fibroblasts and not of the unmethylated cells. This assumes that methylated FM fibroblasts were present in our culture, which acc

• Further support for the hierarchical two

  2018-10-20

  

  Further support for the hierarchical two-stem-cell model came with the discovery of an additional reserve ISC marker locus, Hopx, encoding an atypical homeodomain protein with functions in early heart development (Chen et al., 2002). An IRES-CreERT2 cassette inserted into the endogenous Hopx locus r

• During embryonic development retinoic acid RA acts as

  2018-10-20

  

  During embryonic development, retinoic hedgehog pathway (RA) acts as a morphogen, providing signals that instruct commitment of unspecified precursors toward separate cell fates, thereby helping to mediate tissue patterning and organogenesis (Duester, 2008; Kumar and Duester, 2011; Ross et al., 200

• Mass spectrometry MS based proteomics is a powerful approach

  2018-10-20

  

  Mass spectrometry (MS)-based proteomics is a powerful approach for the comparative analysis of protein verbascoside between cell populations. Global approaches have been used to define the MSC proteome (Delorme et al., 2008; Mareddy et al., 2009; Mindaye et al., 2013a, 2013b) and to track the change

• br Resource table Resource details

  2018-10-20

  

  Resource table. Resource details Macaca fascicularis iPS THZ1 Hydrochloride ATCi-MF1 were generated from adult skin-derived fibroblasts by transduction with non-integrative Sendai viruses coding for the reprogramming factors OCT3/4, KLF4, SOX2 and c-MYC (Ban et al. 2011; Zapata-Linares et al. 2

• BI2536 br Towards successful transplantation of human ITT Wh

  2018-10-20

  

  Towards successful transplantation of human ITT Where there is no risk of neoplastic contamination of the tissue that could lead to retransmission of cancer BI2536 back to the cured patient, autotransplantation of testicular tissue pieces may be considered for fertility restoration. It has the a

• Here we report for the first

  2018-10-20

  

  Here, we report for the first time that the mouse eye possesses a primitive c-Kit+ cell that is self-renewing, clonogenic and multipotent, the three critical identifiers of tissue specific stem/progenitor topotecan (Weissman, 2000). In addition, lineage tracing techniques in vivo demonstrate that t

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