• br Conclusion Cellular reprogramming is an inefficient proce

  2018-10-20

  

  Conclusion Cellular reprogramming is an inefficient process and obtaining the rare reprogramming intermediates is a major hurdle in understanding this important event at the molecular level. The application of certain techniques that require higher cell numbers such as transcription factor UNC202

• br Materials and methods br Results br

  2018-10-20

  

  Materials and methods Results Discussion We have identified and begun to characterize a novel miRNA, miR-410, which on inhibition of BMP signaling by Noggin, is down-regulated in the adult SVZ. Over-expression of miR-410 in SVZ neurospheres inhibited neuronal differentiation and increased t

• CSCs are identified either by surface

  2018-10-20

  

  CSCs are identified either by surface markers and up-regulation of transcription factors/other genes involved in stem cell pathways or by functional assays to characterize stem like properties like drug efflux, quiescence and self-renewal (Moserle et al., 2010). Studies have reported enrichment of C

• In this regard murine ESC derivatives bearing

  2018-10-20

  

  In this regard, murine ESC derivatives bearing EGFP transcriptionally controlled via the promoter of the HCN4 gene were reported to coexpress EGFP, HCN4, and other cardiac markers in spontaneously beating foci (Morikawa et al., 2010). Yet, after the EGFP-positive fraction was subjected to cell sorti

• There are three possible explanations for our findings First

  2018-10-20

  

  There are three possible explanations for our findings. First, it is possible that the reprogramming process resulted in iPSCs that were solely derived from methylated FM fibroblasts and not of the unmethylated cells. This assumes that methylated FM fibroblasts were present in our culture, which acc

• Further support for the hierarchical two

  2018-10-20

  

  Further support for the hierarchical two-stem-cell model came with the discovery of an additional reserve ISC marker locus, Hopx, encoding an atypical homeodomain protein with functions in early heart development (Chen et al., 2002). An IRES-CreERT2 cassette inserted into the endogenous Hopx locus r

• During embryonic development retinoic acid RA acts as

  2018-10-20

  

  During embryonic development, retinoic hedgehog pathway (RA) acts as a morphogen, providing signals that instruct commitment of unspecified precursors toward separate cell fates, thereby helping to mediate tissue patterning and organogenesis (Duester, 2008; Kumar and Duester, 2011; Ross et al., 200

• Mass spectrometry MS based proteomics is a powerful approach

  2018-10-20

  

  Mass spectrometry (MS)-based proteomics is a powerful approach for the comparative analysis of protein verbascoside between cell populations. Global approaches have been used to define the MSC proteome (Delorme et al., 2008; Mareddy et al., 2009; Mindaye et al., 2013a, 2013b) and to track the change

• br Resource table Resource details

  2018-10-20

  

  Resource table. Resource details Macaca fascicularis iPS THZ1 Hydrochloride ATCi-MF1 were generated from adult skin-derived fibroblasts by transduction with non-integrative Sendai viruses coding for the reprogramming factors OCT3/4, KLF4, SOX2 and c-MYC (Ban et al. 2011; Zapata-Linares et al. 2

• BI2536 br Towards successful transplantation of human ITT Wh

  2018-10-20

  

  Towards successful transplantation of human ITT Where there is no risk of neoplastic contamination of the tissue that could lead to retransmission of cancer BI2536 back to the cured patient, autotransplantation of testicular tissue pieces may be considered for fertility restoration. It has the a

• Here we report for the first

  2018-10-20

  

  Here, we report for the first time that the mouse eye possesses a primitive c-Kit+ cell that is self-renewing, clonogenic and multipotent, the three critical identifiers of tissue specific stem/progenitor topotecan (Weissman, 2000). In addition, lineage tracing techniques in vivo demonstrate that t

• Here we describe the characteristics of

  2018-10-20

  

  Here, we describe the characteristics of a novel SeVdp-iPS vector (SeVdp(KOSM)302L) containing miR-302a target sequences at the 3′-UTR of the L gene. This vector can be used for the efficient reprogramming of MEFs into transgene-free iPSCs without the aid of siRNAs, observed using human embryonic fi

• Beyond the established role of OH D in VDR

  2018-10-20

  

  Beyond the established role of 1,25(OH)D3 in VDR signaling, the biological function of vitamin D precursors in mediating non-VDR dependent events remains controversial. Mutations in 7-dehydrocholesterol reductase are associated with Hh defects in mammals (Koide et al., 2006). Cell culture studies de

• Small or immature teratomas are particularly

  2018-10-20

  

  Small or immature teratomas are particularly hard to detect due to the lack of tissues with high secretion levels such as gland-like structures. In line with that, we found one teratoma in our test set for which none of the eight tested biomarkers was positive. Histological characterization showed t

• There are multiple ways whereby oxidative stress may promote

  2018-10-20

  

  There are multiple ways whereby oxidative stress may promote FOXO activation. For example, FOXO proteins can directly sense ROS through the ability of ROS to induce disulfide bridges between cysteine residues on the FOXO protein, resulting in FOXO activation and transcription of ROS-removal BIRB796

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