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Introduction Human cytomegalovirus CMV is a herpesvirus whic
2020-01-10
Introduction Human cytomegalovirus (CMV) is a herpesvirus which has a ubiquitous and worldwide distribution, and is the most frequent cause of congenital infection (Kenneson and Cannon, 2007). The prevalence is around 0.5–1% of all live births and is the leading cause of sensorineural hearing loss
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br Conclusion The past few years have witnessed
2020-01-10
Conclusion The past few years have witnessed substantial progress in understanding the structural mechanisms of substrate recognition and the reactions catalyzed by the O-GlcNAc-cycling enzymes, but more work remains. In particular, future research will be needed to establish how OGT and OGA inte
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In summary the metabolism of GEF
2020-01-10
In summary, the metabolism of GEF in HLM and MLM was extensively studied using a LC–MS-based metabolomic approach. This study identified a total of 34 metabolites and adducts related to GEF (Fig. 10) and identified three new potential reactive metabolites, including two aldehydes and one iminium. Pr
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From our array results Supplemental
2020-01-09
From our array results (Supplemental Fig. S2), we found that differential lncRNA profiling exhibited much greater disparity compared to differential gene profiling in CD28nullCD8+ T cells, indicating that differentially expressed lncRNA(s) would serve as ideal hallmarks. Moreover, we were fortunate
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WEHI-539 In addition to glutamatergic inputs the RTn
2020-01-09
In addition to glutamatergic inputs, the RTn integrates cholinergic, serotonergic and noradrenergic synapses of fibers coming from nuclei located in the brainstem (Asanuma, 1992, Morrison and Foote, 1986, Pare et al., 1988) involved in the alternating firing mode and in the frequency changes of reti
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Initially studies of GPCRs predominantly
2020-01-09
Initially, studies of GPCRs predominantly assessed the signalling pathways downstream of receptors on the cell surface. There is now an understanding that GPCRs can localize to and signal from various intracellular compartments, such as the nucleus (reviewed in [40]). These intracellular pools of re
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The genomic DNA sequences of CXCL and CXCRs were
2020-01-09
The genomic DNA sequences of CXCL8 and CXCRs were retrieved from the fugu genome database v4.0. The intron–exon boundaries were identified with the corresponding cDNA sequences. This comparison revealed that the fugu gene is about 1.13kb long and contains four exons separated by three introns (top p
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br Conclusion br Conflict of interest br Author contribution
2020-01-09
Conclusion Conflict of interest Author contributions Acknowledgements Piyamas Kanokwongnuwut was supported by the Development and Promotion of Science and Technology Talent Project (DPST), Royal Thai Government Scholarship. Funding for the work was provided by the Attorney General’s Depa
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While previously reported optimizations on compound focused
2020-01-09
While previously reported optimizations on Cytidine 5-triphosphate focused on the phenyl ring A () and substituents on isoxazole ring, other alternatives to replace isoxazole ring were never explored. Herein, we propose to replace the isoxazole with its bioisosteric substituted phenyl ring B () to
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br Introduction Hematopoietic stem cells and leukemic stem
2020-01-09
Introduction Hematopoietic stem N-acetyl D-galactosamine sale and leukemic stem cells (HSCs and LSCs, respectively) both have a capacity of self-renewal. Whereas HSCs give rise to all blood lineages during lifetime hematopoiesis, LSCs are responsible for the initiation and propagation of leukemi
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br Discussion br Conflicts of interest br
2020-01-08
Discussion Conflicts of interest Acknowledgment Introduction Ewing\'s sarcoma (EWS) is a bone cancer arising mostly in children. In 1921, EWS was originally described as “diffuse endothelioma of bone” by Dr. James R. Ewing, an American pathologist [1]. In 1992, Ewing sarcoma breakpoint r
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br Disclosures br Acknowledgements This work was supported
2020-01-08
Disclosures Acknowledgements This work was supported in part by grants from the Ministerio de Ciencia e Innovación, Spain (SAF2010-22051) and Xunta de Galicia, Spain (INCITE08PXIB203092PR). Introduction Ca is a key element in cardiac excitation–contraction (EC) coupling. In each heartbeat,
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The applications of fungal enzymes in
2020-01-08
The applications of fungal enzymes in paper industry involve biobleaching of pulp, pulp de-inking, degradation of dissolved and suspended organic compounds in concentrated effluents of mills and enhanced fibrillation. Enzymes usage is encouraged in paper industry in order to reduce the use of chemic
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The synthesis of compounds a
2020-01-08
The synthesis of compounds 7a and 7b are outlined in Scheme 2. Compound 5 was obtained by di-tert-butyl pyrocarbonate protection of amiodarone hcl 4a. Then, compounds 6a and 6b were obtained by amination of the fluoride with a morpholino and dimethylamine, respectively. Target compounds 7a and 7b w
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br The contribution of Interference
2020-01-08
The contribution of Interference RNA and epigenetic in OA attenuation Interference RNA, a cellular mechanism for post-transcriptional gene silencing that is associated with mRNA. The potential of RNAi has successfully silenced the wide range of protein coding genes. Its high specificity sanctions
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