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Recently Zhao et al have been carried out a study
2019-12-26
Recently, Zhao et al. have been carried out a study to investigate the relationship between eNOS-4b/a polymorphism and the risk of LCPD in a Chinese population. Their results demonstrated that eNOS polymorphisms may be involved in the etiology of LCPD. However, the number of studies conducted to exa
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It is noteworthy that little is known
2019-12-26
It is noteworthy that little is known as to the role of autophagy in regulation of eNOS phosphorylation and eNOS uncoupling. eNOS monomers, but not eNOS dimers could be degraded by ubiquitination [39], harbingering the existence of protein degradation pathways in modulation of eNOS turnover and acti
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Collagen type is the most abundant extracellular
2019-12-26
Collagen type 1 is the most abundant extracellular matrix (ECM) protein found in vertebrates. Collagen exerts its role as a load bearing structure and regulator of cell function, only after it has assembled into fibrils., The equilibrium between the synthesis and degradation of collagen fibrils and
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Currently two approaches can be used individually or
2019-12-26
Currently, two approaches can be used individually or combinedly to overcome weak immunogenicity of subunit PP 3 (Bookstaver et al., 2018; Moyle, 2017; Vartak and Sucheck, 2016). The first is to design particulate antigens. Virus-like particles (VLPs), for example—mainly derived from the capsid prot
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Pyruvate dehydrogenase multienzyme complex PDHc catalyzes th
2019-12-26
Pyruvate dehydrogenase multienzyme complex (PDHc) catalyzes the oxidative decarboxylation of pyruvate, and subsequently acetylates coenzyme A (CoA) to acetyl-CoA during the tricarboxylic Clofazimine metabolic pathway using thiamine diphosphate (ThDP) and Mg2+ as cofactors. PDHc poses a key role in
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br DUBs in regulation of
2019-12-26
DUBs in regulation of critical steps in tumor metastasis Tumor metastasis comprises a complicated series of biological processes in terms of the invasion-metastasis cascade that requires cancer JNJ-38877605 to (1) migrate and invade from the origin sites through the extracellular matrix (ECM) to
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In the case of high
2019-12-26
In the case of high-fidelity polymerases, we propose that water is used to achieve negative selection against nucleotide binding. With specialized DNA polymerases, we propose that nucleobase desolvation plays a different yet important role in allowing these enzymes to replicate damaged DNA. In this
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For LAU extracted ion chromatograms
2019-12-26
For LAU 399, extracted Pam3CSK4 chromatograms of the blank, t0, and t120 samples for the diagnostic product ion m/z 163.0216 are provided in Fig. S11, and extracted ion chromatograms of the t120 sample for m/z 163.0216 (diagnostic product ion), and m/z 308.1677 and 306.1522 (metabolites) are shown
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Since free testosterone diffuses into
2019-12-26
Since free testosterone diffuses into a target organ [1], a remarkable increase in free testosterone in plasma is expected to enhance androgen response in target organs including the prostate. In fact, the results of the present study showed testosterone and DHT levels, and mRNA expression levels of
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br GPCRs form heterotetramers In addition
2019-12-24
GPCRs form heterotetramers In addition to homodimers and heterodimers, for several family A receptor heteromers, experimental evidence supports the presence of higher order rearrangements as tetrameric structures, comprised of two different homodimers, each able to signal with its preferred G pro
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CFSs are recognized as a driver of genome instability
2019-12-24
CFSs are recognized as a driver of genome instability in human cells and are hotspots for deletions or translocations in cancers (Richards, 2001). The generally accepted model for their expression is that the CFS locus shows a delay in chromatin condensation in early mitosis caused by the persistenc
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BR stimulated PA formation via the DGK
2019-12-24
BR-stimulated PA formation via the DGK pathway might have many effects in regulation of cell metabolism. For example, PA originated from DGKs pathway plays important roles in activation of NADPH oxidases, thus turning on ROS signaling [23]. PA is also connected to regulation of respiration processes
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L-Glutathione Reduced The aberrant methylation of genes that
2019-12-24
The aberrant methylation of genes that suppress tumorigenesis appears to occur early in tumor development and increase progressively, eventually leading to the malignant phenotype [35]. Genes involved in every step of tumorigenesis can be silenced by this epigenetic mechanism. Hypermethylation of pr
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There is a large interindividual
2019-12-24
There is a large interindividual difference in intestinal cholesterol Raltitrexed of cholesterol that is mainly due to genetic variation [15], [19]. Single nucleotide variation (SNV) in NPC1L1 and, ABCG5 and ABCG8 key modulators of cholesterol influx and efflux into intestinal mucosal cells, respec
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br Materials and methods br Results and discussion br
2019-12-24
Materials and methods Results and discussion Conclusion The glycyl endopeptidase from papaya latex was partitioned using aqueous two-phase (10%PEG 6000–10% (NH4)2SO4) in combination with ammonium sulphate precipitation (40–60% saturation). The partially purified glycyl endopeptidase showed
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