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In the present study we
2019-12-04
In the present study we investigated the effect of morphine withdrawal on G-protein coupling to opioid and ET receptors in neonatal rats. Morphine-induced G-protein activation was significantly higher in neonatal rats undergoing morphine withdrawal; suggesting enhanced coupling of the receptors to
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br Funding This work was supported by
2019-12-04
Funding This work was supported by the National Natural Science Foundation of China (grant number 81671411); Beijing Natural Science Foundation (grant number 7162062); Beijing Nova Program Interdisciplinary Cooperation Projects (grant number Z161100004916045); Beijing Municipality Health Technolo
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The use of recombinant ER and ER binding assays
2019-12-04
The use of recombinant ERα and ERβ binding assays offers a relatively inexpensive, rapid technique for screening compounds for potential direct Demethoxycurcumin australia receptor modulatory activity and understanding the mechanisms of existing herbal medicines. For background on the protein produ
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Materials and Methods br Results br Discussion For several d
2019-12-04
Materials and Methods Results Discussion For several decades, the diagnosis of translocation-associated childhood sarcomas with overlapping morphological characteristics has been facilitated by pathognomonic gene fusion detection through RT-PCR or FISH. However, these assays have several shor
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br Materials and methods br Results br
2019-12-04
Materials and methods Results Discussion PKA and Epac are two principal effector proteins involved in cAMP signaling; they are expressed in a wide range of tissues and control diverse biological functions [10]. The existence of two cAMP effectors provides more precise regulation of cAMP sig
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Our structures also provide new insights into CRTH drug
2019-12-03
Our structures also provide new insights into CRTH2 drug development. The ligand binding pocket revealed by our structures comprises many aromatic residues and a few polar residues at the distal end. Correspondingly, most CRTH2 antagonists share a similar structural feature characterized by an aceta
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ERR induces the expression of P
2019-12-03
ERRγ induces the expression of P450c17 in MA-10 cells and in mouse primary Leydig cells (Fig. 2). Deletion mutant analysis of putative ERRγ-binding sites in the P450c17 promoter suggested that only the proximal third site located between −269 bp and −136 bp within the P450c17 promoter is functional
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br Materials and methods br Results br
2019-12-03
Materials and methods Results Discussion PKA and Epac are two principal effector proteins involved in cAMP signaling; they are expressed in a wide range of tissues and control diverse biological functions [10]. The existence of two cAMP effectors provides more precise regulation of cAMP sig
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Additionally in the presented study both the NSE values and
2019-12-03
Additionally, in the presented study both the NSE values and MFI levels of the CD45−CD34 + CXCR7+ tlr signaling correlated positively with the inflammatory parameter – CRP. CXCR7 expression has been found to be enhanced during pathological processes such as inflammation and neoplasms (Janssens et a
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br No Evidence for Further ET Receptor Subtypes
2019-12-03
No Evidence for Further ET-Receptor Subtypes Further receptor subclassifications have been proposed including suggestions that ETB could be subdivided into ETB1, present on endothelial cells, and ETB2 on smooth muscle cells, but there currently is no evidence that the receptors expressed by these
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Epitope analyses of AT AA and
2019-12-03
Epitope analyses of AT1-AA and ET-AA indicate that the rora of both autoantibodies are located at the second extracelluar loop of both receptors. The specific epitopes for both autoantibodies are similar to what was reported previously in a cohort of patients from Brazil [6] and for AT1-AA also fro
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Given that CE plays an essential role in schistosome invasio
2019-12-03
Given that CE plays an essential role in schistosome invasion, its immunoreactivity and protective potential is of significant interest. The native form of SmCE was found to be poorly immunogenic in immunized mice. An earlier study found that sera from S. mansoni patients have shown the presence of
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br Materials and Methods br Acknowledgements We thank the
2019-12-03
Materials and Methods Acknowledgements We thank the staff of beamlines ID29 and ID30A-1 of the European Synchrotron Radiation Facility. This work was supported by, the Marie Curie Career Integration Grant (PCIG13-GA-2013-630755), the Israel Science Foundation (Grant 1383/17) and the Israeli Ca
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Ubiquitination is a covalent attachment of amino acid ubiqui
2019-12-03
Ubiquitination is a covalent attachment of 76 amino 1661010 ubiquitin molecules to target proteins, either as single moieties (mono-ubiquitination) or as poly-ubiquitin chains of different structures, formed through isopeptide bonds between specific lysines of one ubiquitin residue (for example K48
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In normal cells the apoptotic stimuli lower the expression
2019-12-03
In normal cells, the apoptotic stimuli lower the expression level of antiapoptotic proteins by increasing turnover rate and preventing the constant degradation of proapoptotic proteins. Thus, the dysregulation of anti-/pro-apoptotic proteins will confer the survival of cancer FTY720 Phosphate austra
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