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br Methods br Results br Discussion Chronic stress renders i
2024-04-09
Methods Results Discussion Chronic stress renders individuals vulnerable to diseases, and this effect might be, at least partially, mediated by stress hormone-induced immunosuppression. Therefore, investigating the effects of catecholamines on immune RO4987655 receptor is of high relevance
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In the past few years several experimental findings have
2024-04-09
In the past few years, several experimental findings have demonstrated a pivotal involvement of adenosine also in driving the phenotypic switch of macrophages. In particular, the stimulation of A2A and A2B receptors seems to play a critical role in switching macrophages from M1 to M2 phenotype [37,6
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Specifically equity injections in a multinational affiliate
2024-04-09
Specifically, equity injections in a multinational affiliate X located in an ACE country can be passed on as lending to another group member Y located in a different country with a high corporate income tax rate. For the group member Y, the interest on the loans is tax deductible, and at the same ti
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The anorexic effect observed when AR is infused into
2024-04-09
The anorexic effect observed when AR231630 is infused into the VTA could be the result of the DA release inhibition, as previously described [11]. However, there is also a hedonic aspect in feeding that possibly involves dopaminergic mechanisms of reward. Helm et al. showed a functional link between
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Drug resistance development often involves structurally un r
2024-04-09
Drug resistance development often involves structurally un-related drugs and, specifically both conventional and targeted agents. IGROV-1/Pt1 blasticidin are characterized by resistance to cisplatin and reduced sensitivity to inhibitors of EGF-R and MEK, the up-stream activator of ERK1/2, associate
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Various cardiovascular diseases show a high occurrence of
2024-04-09
Various cardiovascular diseases show a high occurrence of autophagosomes. Whereas basal autophagy is required for the proper functioning of cardiomyocytes [82], the deletion of Atg5 gene in myocardium shows a high risk of cardiomyopathy [83]. Hamacher et al. observed that an upregulation of Bnip3, a
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At first the APC is a
2024-04-09
At first, the APC is a 310kDa protein divided into three domains such as N-terminal, central core and C-terminal domain [102], plays a major role to regulate the Wnt signaling pathway in human cancer by translating β-catenin from the bethanechol chloride to the nucleus [103]. The SIRT1 regulates the
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How does the ATM to ATR switch occur at
2024-04-09
How does the ATM-to-ATR switch occur at DSBs? The progressive attenuation of ATM activation could be attributed to the loss of DNA structures that activate ATM, or to the generation of DNA structures that interfere with ATM activation. Our finding that SSOs do not directly affect the binding of puri
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br Materials and methods br Results RT PCR showed that
2024-04-09
Materials and methods Results RT-PCR showed that both arginase 1 and 2 were expressed in the OB of Korean roe deer (Fig. 1). Immunoblotting detected arginase 1 in the OB of roe deer (Fig. 2A, left lane) at a molecular weight of approximately 37kDa, which is the size of the enzyme in the rat
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The major phase trial NCT enrolled
2024-04-08
The major phase 2 trial (NCT01343966) enrolled 431 participants with mild to moderate AD who received either low-dose SC crenezumab 300 mg or placebo biweekly (n = 184) or high-dose intravenous crenezumab 15 mg/kg or placebo every 4 weeks (n = 247) for 68 weeks 38, 40. No significant treatment benef
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There are several reports providing evidences
2024-04-08
There are several reports providing evidences that functional and mechanistic connection between Sirt1 and LKB1/AMPK in metabolic regulation [26], [32], [33]. It has been reported that the deacetylation of LKB1 by Sirt1 is one of the determining factors of the subcellular localization of LKB1. In ag
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The chronic induction of skeletal muscle AMPK
2024-04-08
The chronic induction of skeletal muscle AMPK activity is an attractive therapeutic approach for DMD, as it addresses multiple cellular pathways needed for powerful phenotypic plasticity, including activation of the slow oxidative myofiber program, corrective autophagic signaling, as well as regulat
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br Impact of global AHR deficiency on diet induced obesity
2024-04-08
Impact of global AHR deficiency on diet-induced obesity Two subsequent studies in which AHR function was affected at the whole animal level corroborated the role of AHR in dietary obesity. Xu et al. [14] showed that on a high-fat diet, both AHR-deficient Ahr−/− and hemizygous Ahr+/− mice gained s
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angiotensin receptor blockers In another study authors found
2024-04-08
In another study, authors found that ADORA1 were present on the intrinsically photosensitive retinal ganglion angiotensin receptor blockers (ipRGCs), and application of adenosine to rat retinas reduced light-evoked spiking of ipRGCs through suppression of a cAMP-mediated pathway (Sodhi and Hartwick,
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We have previously reported alterations
2024-04-08
We have previously reported alterations of the thymus in AChR-MG patients, especially in their germinal center Erastin (defined as CD19+CD38+ cells by flow cytometric analysis). First, we found that, in MG thymi, this subset failed to show the normal down-regulation of Bcl-2, suggesting that autore
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