• The present study found a significant negative correlation

  2019-09-16

  

  The present study found a significant negative correlation between miR-152-3p and CDK8 expression in human HCC tissues. We also validated that CDK8 was a direct target of miR-152-3p, and overexpression of miR-152-3p inhibited proliferation and induced apoptosis in HCC 3X FLAG Peptide by suppressing

• In present study we measured

  2019-09-16

  

  In present study, we measured the methylation and Tunicamycin and levels of CDKL2 in HCC tissues and cell lines. Meanwhile, correlations between the methylation and mRNA expression, clinicopathological features were evaluated. Materials and methods Results Discussion DNA methylation is a

• br Results br Discussion CCA is

  2019-09-12

  

  Results Discussion CCA is a fatal tumor originating from the intrahepatic bile duct and the prognosis is very poor (Hoyos et al., 2018). CCA is one of the most dangerous primary liver malignant tumors and the most common malignant tumor of the biliary tract worldwide. However, the underlying m

• Concholepas concholepas our model species for

  2019-09-12

  

  Concholepas concholepas, our model species for this study, is a marine gastropod found along the Chilean coast that has become commercially important [25], [26], [27]. Until now, the main focus of immunology related to C. concholepas is the production of a novel hemocyanin that has been useful for t

• C PHNO has been described as a

  2019-09-12

  

  [11C]-(+)-PHNO has been described as a full agonist at both D2 and D3 receptors [54,55]. [11C]-(+)-PHNO was initially developed as a PET radiotracer for imaging the high affinity state of the D2 receptor (i.e., highD2) as a means of measuring synaptic dopamine changes in response to pharmacologic ch

• Protease Inhibitor Library br Authors contributions br Ackno

  2019-09-12

  

  Authors’ contributions Acknowledgements Introduction Retinoic Protease Inhibitor Library is a key signalling molecule in healthy development and in differentiation of stem cells, albeit uncontrolled levels of retinoic acid can lead to mutagenesis [1]. In eukaryotes retinoic acid is made by

• br Acknowledgements We thank Jeffrey D Konowalchuk and John

  2019-09-12

  

  Acknowledgements We thank Jeffrey D. Konowalchuk and John Sony Robbins for their technical assistance. This work was supported by Natural Sciences and Engineering Research Council of Canada (NSERC) grants to DRB (RGPIN-2013-355303) and MB (RGPIN-2014-96395). AMR was supported by NSERC Vanier Doct

• While lowering the TID exposure of electronics is fairly

  2019-09-12

  

  While lowering the TID exposure of electronics is fairly straightforward, there are other Conoidin A clinical induced effects that are not as easily mitigated, especially with COTS components. Single Event Effects (SEE) occur when a high-energy particle strikes the active area of an integrated circ

• Consistent with previous simulations on the

  2019-09-12

  

  Consistent with previous simulations on the DFG-Asp-out/-in interconversion of Abl kinase, we only observe the DFG flip with protonated Asp747 (Shan et al., 2009). We showed previously that the pKa for the DFG-Asp in Abl is elevated at 6.5. Further “constant pH” simulations whereby protonation event

• The indigenous populations living at

  2019-09-12

  

  The indigenous populations living at high mountain regions of the Himalayas represent successful human BAMB-4 pathway to hypoxia. These populations have undergone selective positive natural selection over millennia across several genomic loci and exhibit unique respiratory, cardiopulmonary and haema

• It has been reported that

  2019-09-11

  

  It has been reported that vernolic Ketoprofen accumulation in transgenic Arabidopsis seeds expressing a Δ12-epoxygenase often resulted in failure of germination and impaired growth and development (Singh et al., 2001). Similar phenomena were also reported for transgenic Arabidopsis seeds with accumu

• Dopamine activity in the PFC and striatum may be antagonisti

  2019-09-11

  

  Dopamine activity in the PFC and striatum may be antagonistic, meaning that lower levels of dopamine in the striatum tend to correspond to higher levels of dopamine in the PFC and vice versa (Cools and D\'Esposito, 2011; Tunbridge et al., 2006). Human PET studies have reported that dopaminergic PFC

• To identify and characterize new possible molecular targets

  2019-09-11

  

  To identify and characterize new possible molecular targets, the mechanisms of various kinds of TCDD toxicities that occur by abnormal regulation in the downstream of AhR signals have been studied (Yoshioka et al., 2011). Experimental evidence has revealed that prostanoids (i.e., prostaglandins and

• Repulsive interactions towards undesirable substrates

  2019-09-11

  

  Repulsive interactions towards undesirable substrates are arguably a very efficient means to implement specificity [8]. In particular, it could be assumed that discrimination against a substrate that is larger than the cognate substrate may be achieved easily by restricting the active site and explo

• br Materials methods br Results and discussion The compariso

  2019-09-11

  

  Materials & methods Results and discussion The comparison of BFI methods (Table 1) shows that Phosphatesmo failed to detect seminal fluid in all samples. This observation is concordant with other studies that investigated water-exposed seminal fluid stains [6], [7]. The Phosphatesmo test is us

16640 records 1008/1110 page Previous Next First page 上5页 10061007100810091010 下5页 Last page