• br Discussion CML was the

  2019-05-09

  

  Discussion CML was the first malignancy to be linked to a clear genetic abnormality, the Philadelphia chromosome. This chromosomal abnormality is so named because of the city in which it was first discovered and described in 1960 by Peter Nowell and David Hungerford [1]. The fusion protein result

• Consequently in asymptomatic individuals multiple and repeat

  2019-05-09

  

  Consequently, in asymptomatic individuals, multiple and repeated ECG recordings rather than drug testing are recommended for detecting the transient appearance of a spontaneous type 1 ECG, which may indicate the future development of arrhythmic events. Moreover, in addition recording at higher lead

• Primary lymphoma of bone is an uncommon clinical entity and

  2019-05-09

  

  Primary lymphoma of bone is an uncommon clinical entity and accounts for less than 5% of malignant bone tumors, 4–5% of extra nodal lymphoma and less than 1% of all non-Hodgkin\'s lymphoma. Diffuse large-B-cell lymphoma (DLBCL) accounts for the majority of cases of PBL [2]. The varied clinical and h

• Pain flare defined as a

  2019-05-09

  

  Pain flare, defined as a “temporary worsening of bone pain in the treated metastatic site” [2], has been previously documented as a side effect of radiopharmaceutical and hormonal therapy [2,10,11]. Although it is a recognized side-effect of radiation treatment as well, only recent studies have atte

• The standard therapy for chordoma is

  2019-05-09

  

  The standard therapy for chordoma is excision. Local recurrence, but not metastasis, is a major determinant of prognosis. Because local recurrence is related to initial surgical margin and intra-operative tumor cell contamination, achieving a safe margin is very important. Boriani [6] reported 153 c

• br Interpretation of identified genetic variants and genetic

  2019-05-09

  

  Interpretation of identified genetic variants and genetic counseling Although the current expert consensus statement recommends that comprehensive or BrS1 (SCN5A) targeted BrS genetic testing can be useful for genetic testing [63], not all the published SCN5A mutations in BrS have been subjected

• NCS is a rare syndrome In case series of

  2019-05-08

  

  NCS is a rare syndrome. In case series of NCS 14–47% were associated with of lymphoproliferative disorders [reviewed in [12]]. Survival is usually dictated by the underlying disease and short in the setting of aggressive malignancies. Since NCS may be a manifestation of an underlying malignancy it h

• br Should child growth replace diarrhoea

  2019-05-08

  

  Should child growth replace diarrhoea as the primary child health outcome for sanitation trials? We appreciate Derek Headey\'s comment in relation to our trial that the window of opportunity to plausibly affect growth faltering is from in utero up to 24 months, and therefore that sanitation trials

• br Conflict of interest br Acknowledgment br

  2019-05-08

  

  Conflict of interest Acknowledgment Introduction Several investigators recently showed that the superior vena cava (SVC) was one of the major foci for initiating atrial tachyarrhythmias, such as atrial tachycardia (AT) and atrial fibrillation (AF) [1–4]. Conduction block between the atrium

• A structured inherited arrhythmia or heart disease clinic

  2019-05-08

  

  A structured inherited arrhythmia (or heart disease) clinic provides the platform for optimized multidisciplinary evaluation and management of patients and families with suspected inherited heart disease. The collective efforts of the core staff and access to a variety of experts in related discipli

• br Escribir y destacar promoci n la

  2019-05-08

  

  Escribir y destacar (promoción 1975-1985): la identidad por las diferencias ¿Cómo escribir dentro de un mercado de tantos competidores para un país de escasos lectores? En México, ni siquiera los estudiantes de la universidad consumen libros y hay más papelerías que librerías (Zaid 2013: 143-154

• El caso argentino sobre la literatura fant stica puede

  2019-05-08

  

  El caso argentino sobre la literatura fantástica puede ser interpretado de modo similar al de Mukarovsky, thereby propósito de la obra de arte como hecho semiológico (estético/social): por un lado, se encuentra el signo poético, que Macedonio y Borges recuperan en la obra literaria mediante sus cuen

• ARCA As Becerra Posada writes attention must be given to

  2019-05-08

  

  As Becerra-Posada writes, attention must be given to the development of capacities and structures for taking health into account in all policies. But should the public health ARCA also give attention to raising the standing of health on the political agenda and to helping induce political solutions

• Este trabajo llama la atenci n sobre dos vol

  2019-05-08

  

  Este trabajo llama la atención sobre dos volúmenes de poesía (, de 1916, y , de 1967) ligados de modo estrecho AMN-107 dos momentos clave de la historia provincial: por un lado, el año del Centenario de la Independencia Nacional —cuya declaración había tenido lugar, como es sabido, en 1816 precisame

• br Identidade negra e quilombola O

  2019-05-08

  

  Identidade negra e quilombola O uso da expressão “remanescentes” para classificar os agrupamentos negros, enquanto unidades que guardam correspondência histórica com os quilombos, motivou reflexões sobre seu significado. Adotamos o entendimento de que ao contrário do sentido de sobra ao qual pode

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