• While resistance to imatinib is rare in

  2019-06-21

  

  While resistance to imatinib is rare in patients treated in CML-CP, resistance does eventually develop in the majority of patients treated in the advanced phases. In a high proportion of patients who develop secondary resistance after initial responses, point mutations in the BCR-ABL kinase domain h

• The functional analysis of this

  2019-06-21

  

  The functional analysis of this V1764fsX1786 mutation is shown in Fig. 3B; no current was observed, indicating severe loss-of-function. Although we did not investigate the mechanisms of this complete reduction in Na+ current in this mutation, Herfst et al [19]. reported a similar frameshift mutation

• In the management of BrS patients it is important

  2019-06-21

  

  In the management of BrS patients, it is important to avoid or treat certain drugs or circumstances such as a febrile state, electrolyte disturbances (hyperkalemia and hypercalcemia), and the use of class Ia/Ic antiarrhythmic drugs, vagotonic agents, beta-adrenergic antagonists, tricyclic antidepres

• Numerous animal studies have demonstrated beyond doubt that

  2019-06-21

  

  Numerous animal studies have demonstrated beyond doubt that effective inhibition of osteoclastogenesis or osteoclast function significantly reduces metastatic tumour growth in bone [13–20]. Likewise, clinical trials in patients with non-metastatic or metastatic cancers established that treatment wit

• br Discussion Compared to the right ventricular outflow trac

  2019-06-21

  

  Discussion Compared to the right ventricular outflow tract, the LVOT has a more complicated anatomic structure, comprising the mitral annulus, aortic cusps, and LV basal myocardium. The AMC bridges the aortic and mitral valves with fibrous tissue, called the left fibrous trigone [3], and the exte

• Alisol B 23-acetate Pese a su evidente inter s

  2019-06-21

  

  Pese Alisol B 23-acetate su evidente interés a nivel de hipótesis, el plan original de Pay-no no tuvo por qué descarriarse como proyecto literario. Al contrario, el intento por parte de Payno de representar en su novela el desastre nacional ocurrido en la capital de México a partir de la ocupación n

• Previous studies have demonstrated localization of miR stain

  2019-06-20

  

  Previous studies have demonstrated localization of miR-21 staining in stromal Thio-TEPA of OSCC associated with the tongue and mouth floor—this might be a useful prognostic predictor. We also observed miR-21 staining in the stromal cells of tumors. However, since multiple lines of evidence indicate

• There is a lot to celebrate and applaud in this

  2019-06-20

  

  There is a lot to celebrate and applaud in this month\'s issue of , but also some sobering findings and a clear demonstration of the need for more research. To start with the positive, Osman Sankoh and fellow INDEPTH Network colleagues announce a new freely accessible repository of Health and Demogr

• Assim como forma de ep logo que ligue

  2019-06-20

  

  Assim, como forma de epílogo que ligue essa ideia central defendida por nós, citamos o editorial de lançamento da revista Araucaria de Chile, que, em 1978, afirmava: Bien se sabe que Chile no es una isla ni su tragedia combate un accidente ni un caso de excepción en América Latina. Su situación se

• Si bien existen otras bases

  2019-06-20

  

  Si bien existen otras bases de datos similares como Scielo y Dialnet, desde las cuales también se podría haber recuperado la documentación pertinente para este estudio, se estimó que redalyc representaba más adecuadamente el mapeo de la región, debido purchase BRL 37344, sodium salt que Scielo tiene

• br Since the launch of the

  2019-06-20

  

  Since the launch of the Every Newborn Action Plan (ENAP) at the World Health Assembly in 2014, and, in 2015, the launch of the UN Secretary General\'s second Global Strategy for Women\'s, Children\'s and Adolescents\' Health, there has been a renewed focus on improving newborn health globally. So

• br Methods This was a retrospective

  2019-06-20

  

  Methods This was a retrospective review of hospital records of dental patients who were treated under GA from January 2006 until November 2015. All participants who attended our hospital were first examined to evaluate their behavioral capabilities and their psychological and physical disabiliti

• br Monitoring coagulation levels Coagulation levels can

  2019-06-20

  

  Monitoring coagulation levels Coagulation levels can be monitored after warfarin treatment by measuring the prothrombin time (PT). However, monitoring is not needed for novel anticoagulants because these drugs have a much wider therapeutic range than warfarin. Nonetheless, in patients at high ris

• br Discussion and outstanding questions Reproductive

  2019-06-20

  

  Discussion and outstanding questions Reproductive endocrine hormones such as inhibin affect breast cancer cell survival in the primary tumour and affect tumour homing and survival in the bone microenvironment. The molecular mechanism driving this effect of hormones in bone is likely to be multifa

• br Results There were cases where cryotherapy was

  2019-06-20

  

  Results There were 232 cases where cryotherapy was used in 214 patients between 1994 and 2015. There were 96 male and 118 female. The age of patients ranged from 4 to 95. All patients had undergone imaging studies for evaluation. A majority of cases consisted of active or aggressive benign tumors

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