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kit inhibitor Introduction Inflammasomes are large cytosolic
2023-10-16
Introduction Inflammasomes are large cytosolic protein complexes with multiple components that trigger a rapid immune response against pathogen-associated molecular pattern kit inhibitor (PAMPs) during pathogen infections or damage-associated molecular pattern molecules (DAMPs) during tissue damag
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br Acknowledgements br Introduction Diabetic complications a
2023-10-16
Acknowledgements Introduction Diabetic complications are responsible for increased morbidity and mortality of diabetic patients. Increased flow of BMI-1 inhibitor through the polyol pathway under conditions of hyperglycemia contributes to the development of diabetic complications. Aldose reduc
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br Conflict s of interest
2023-10-16
Conflict(s) of interest Retinopathy of prematurity (ROP) is a leading cause of childhood blindness Retinopathy of prematurity (ROP) is a disease of premature infants which disrupts normal retinal vascularization (Fleck and McIntosh, 2008). With increased survival of extremely premature infants
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A more versatile cellular delivery system for adenosine
2023-10-16
A more versatile cellular delivery system for adenosine was generated by engineering mouse embryonic stem cells to lack both tetracaine hydrochloride receptor of Adk (Fedele et al., 2004). Using a step-wise differentiation protocol (Okabe et al., 1996) Adk−/− ES cells were differentiated into trans
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The next level of possible correlation and comparison betwee
2023-10-16
The next level of possible correlation and comparison between the α7 and 5HT3 receptors is at the subunit arrangement and protein folding. Crystal structures of the nicotinic and serotoninergic Fmoc-Glu(OtBu)-OPfp receptors [45], [46] reinforced the concept of similarities between these families of
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The gene SRD A encodes the reductase enzyme which converts
2023-10-16
The gene SRD5A2 encodes the 5-α-reductase enzyme, which converts testosterone into dihydrotestosterone. Although dihydrotestosterone levels are considerably lower than testosterone, dihydrotestosterone has a five-fold stronger binding capacity to the androgen receptor and, thereby, a considerably mo
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The following are the supplementary data related
2023-10-16
The following are the supplementary data related to this article. Funding Work in Dr. Rosell's laboratory is partially supported by a grant from La Caixa Foundation, and an Instituto de Salud Carlos III grant (RESPONSE, PIE16/00011). Work in Dr. Cao's laboratory is partially supported by the Maj
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In conclusion AXL overexpression preexisted in a subgroup of
2023-10-16
In conclusion, AXL overexpression preexisted in a subgroup of treatment-naive lung adenocarcinoma specimens harboring an activating EGFR mutation or in those with wild-type EGFR. Anti-AXL therapeutics delivered up front in combination with the EGFR inhibitor might overcome intrinsic or acquired resi
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Amfenac Sodium Monohydrate mg Inactivation of autophagy can
2023-10-16
Inactivation of autophagy can also impact the surface internalization of MHC I molecules, leading to increased antigen presentation. Inactivation of autophagy factors Atg5 and Atg7 in DCs causes elevation of MHC I surface levels by decreasing endocytosis due to a poor recruitment of adaptor-associat
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Inactivation of the proton pump comes with luminal
2023-10-16
Inactivation of the proton pump comes with luminal alkalinization of the targeted vesicles such as lysosomes (Fig. 2b). Lysosome pH can also be raised stoichiometrically by addition of a membrane-permeable weak cetylpyridinium such as methylamine or chloroquine which accumulates in its protonated,
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br Experimental br Results and discussion br Conclusion br
2023-10-16
Experimental Results and discussion Conclusion Acknowledgments This work is supported by the National Basic Research Program of China (973 Program 2016YFA0201201 and 2013CB932702), a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAP
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In Rainey et al published the results of
2023-10-16
In 2008, Rainey et al. published the results of a targeted compound library screen for potential inhibitors of the ATM kinase. In this study, the compound CP466722 was identified as a highly selective and rapidly reversible ATM inhibitor, which did not inhibit PI3K or related PIKK family members. Mo
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The initial demonstration of the potential of
2023-10-13
The initial demonstration of the potential of MALDI-TOF MS for testing antifungal susceptibility of pathogenic fungi came from a proof-of-concept study by Marinach et al. [31] who monitored the changes of the proteome of C. albicans SGX523 exposed to different concentrations of fluconazole. Using a
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98 2 sale Maynard et al demonstrated that serum levels of sF
2023-10-13
Maynard et al. [54] demonstrated that serum levels of sFlt-1 were five times higher in pregnant women with PE than in normotensive women; as a consequence, VEGF and PlGF levels were found to be proportionally reduced in these women [54]. The literature confirms that there is a sharp increase in sFlt
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rho inhibitor Second the phosphorylation events e
2023-10-13
Second, the phosphorylation events (e.g., α-Thr172 and β-Ser108) needed for AMPK activation by small molecules binding at the ADaM or other sites remains unclear. Within the β-GBD, phosphorylation of β1-Ser108 was shown to be required for the activation by small molecules binding in the ADaM site, s
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