• FoxM a downstream target of Gli

  2021-09-30

  

  FoxM1, a downstream target of Gli, has been mainly related to mithramycin regulation and cellular proliferation in tumor (Alvarez-Fernandez and Medema, 2013, Halasi and Gartel, 2013, Teh et al., 2002). Especially, FoxM1 is a regulator of G1/S and G2/M transitions and M-phase progression (Wonsey & F

• The rationale for developing HDACi

  2021-09-30

  

  The rationale for developing HDACi as anticancer agents was based on their ability to induce the hyperacetylation of histones and nonhistone proteins, resulting in increased differentiation, apoptosis, and GDC-0879 arrest of cancer cells 1, 2, 3. HDACi have been used in the treatment of hematologica

• The selection of mutations in vivo with antivirals is

  2021-09-30

  

  The selection of mutations in vivo with antivirals is a complex process involving, among other things, the frequency of a given mutation prior to treatment, the effect of that mutation on viral protein function, and the interplay of a given mutation pattern with host immune mechanisms. Investigation

• GPR is a member of

  2021-09-30

  

  GPR119 is a member of the G protein-coupled receptor family, and is highly expressed in pancreatic β-cells and intestinal endocrine cells. It has been proposed that GPR119 agonists modulate glucose homeostasis by indirectly stimulating glucose-dependent insulin release through enhancing pancreatic c

• br Conclusion We conducted single marker association and

  2021-09-30

  

  Conclusion We conducted single-marker association and haplotype association analyses of genetic mutations in porcine SLA-DOB and CD4 genes with T-lymphocyte subsets, cytokines, and WZ4003 in pregnant Landrace sows and obtained the SNPs and insertion that significantly affected the immunity traits

• br Author contribution br Declaration of interest br Acknowl

  2021-09-30

  

  Author contribution Declaration of interest Acknowledgements This work was supported by National Natural Science Foundation of China (Grants 81473093) and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM1601ZZ-02). Introduction Diabetes represents a majo

• Congenital Gcgr mice exhibit increased hepatic Fgf expressio

  2021-09-30

  

  Congenital Gcgr mice exhibit increased hepatic Fgf21 expression and circulating FGF21 levels. Previous studies by other investigators demonstrated that neutralization of circulating FGF21 with specific 3466 impairs glucose control in these mice [6]. In addition, the FGF21 analog LY2405319 lowers bl

• Heart failure affects approximately million

  2021-09-30

  

  Heart failure affects approximately 6.5 million people over 20 years of age in the United States, with its prevalence estimated to increase about 45% by 2030 to almost 8 million . It is a chronic disease with complex etiology and heterogeneity in its pathological manifestations. Major risk factors f

• As many of the above studies highlight several

  2021-09-30

  

  As many of the above studies highlight, several decades of research on Cx43 has revealed that many of these functional roles are attributed to the C-terminal domain (CT) of this protein which cannot be explained by the formation and existence of intercellular channels. Recent findings on the existen

• Colorectal cancer CRC is the third most common cancer in

  2021-09-29

  

  Colorectal cancer (CRC) is the third most common cancer in men and the second in women worldwide and almost 55% of the cases occur in more developed areas of the world. In the 2012, more than 1.3 million new cases were reported, which accounts for about 10% of the total cancers worldwide (GLOBOCAN,

• Bufexamac australia br Acknowledgement This research was

  2021-09-29

  

  Acknowledgement This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (NRF-2016R1A2B4012818). Oral Bufexamac australia is the most popular administration route due to good pat

• Thermal analysis of the NQ peptide was performed with

  2021-09-29

  

  Thermal analysis of the NQ21 peptide was performed with the Solar CM2203 spectrofluorometer. We prepared three 1 μg/mL peptide solutions with different dopamine receptor antagonist levels (5.0, 7.4, 8.5) in 0.01 M phosphate buffers. Each solution was slowly heated up from 28 °C to 54 °C with a step

• Uracil DNA glycosylase UDG is a highly conserved

  2021-09-29

  

  Uracil-DNA glycosylase (UDG) is a highly conserved damage repair enzyme which can specifically recognize and excise uracil residue within the DNA sequences and actuate the DNA SB525334 sale excision repair (BER) pathway which keeps the maintenance of genomic integrity and stability [[21], [22], [23]

• Interestingly mGlu and mGlu receptors differ notably by

  2021-09-29

  

  Interestingly, mGlu2 and mGlu3 receptors differ notably by their cellular distribution. Whereas mGlu2 receptors are mostly neuronal, mGlu3 receptors are expressed both in glia and in neurons. In neurons, mGlu3 receptors are present at the post-synapse and in presynaptic elements (Tamaru et al., 200

• In the current study we report

  2021-09-28

  

  In the current study, we report the properties of P. anserina mutants carrying mutations in a gene encoding the bi-functional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2). This enzyme catalyzes two opposite reactions (Pilkis et al., 1995, Rider et al., 2004): synthesi

16731 records 606/1116 page Previous Next First page 上5页 606607608609610 下5页 Last page